Publications

  1. Dobson CS, Reich AN, Gaglione S, Smith BE, Kim EJ, Dong J, Ronsard L, Okonkwo V, Lingwood D, Dougan M, Dougan SK, Birnbaum ME. Antigen identification and high-throughput interaction mapping by reprogramming viral entry. Nat Methods. 2022, 19:449-460. PMID: 35396484 View Publication
  3. Hauser BM, Sangesland M, St Denis KJ, Lam EC, Case JB, Windsor IW, Feldman J, Caradonna TM, Kannegieter T, Diamond MS, Balazs AB, Lingwood D, Schmidt AG. Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting. Cell Rep. 2022, 38:110561. PMID: 35303475 View Publication
  5. Read BJ, Won L, Kraft JC, Sappington I, Aung A, Wu S, Bals J, Chen C, Lee KK, Lingwood D, King NP, Irvine DJ. Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens. Cell Rep. 2022, 38:110217. PMID: 35021101 View Publication
  7. Sangesland M, Lingwood D. Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies. Front Immunol. 2021, 12:708882. PMID: 34956170 View Publication
  9. Silva M, Kato Y, Melo MB, Phung I, Freeman BL, Li Z, Roh K, Van Wijnbergen JW, Watkins H, Enemuo CA, Hartwell BL, Chang JYH, Xiao S, Rodrigues KA, Cirelli KM, Li N, Haupt S, Aung A, Cossette B, Abraham W, Kataria S, Bastidas R, Bhiman J, Linde C, Bloom NI, Groschel B, Georgeson E, Phelps N, Thomas A, Bals J, Carnathan DG, Lingwood D, Burton DR, Alter G, Padera TP, Belcher AM, Schief WR, Silvestri G, Ruprecht RM, Crotty S, Irvine DJ. A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity. Sci Immunol. 2021, 6:eabf1152. PMID: 34860581 View Publication
  11. Feldman J, Bals J, Altomare CG, Denis KS, Lam EC, Hauser BM, Ronsard L, Sangesland M, Moreno TB, Okonkwo V, Hartojo N, Balazs AB, Lingwood D*, Schmidt AG*. Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and pre-pandemic coronaviruses. Sci Immunol. 2021, eabl5842. PMID: 34648356 *co-corresponding View Publication
  13. Ronsard L, Yousif AS, Peabody J, Okonkwo V, Devant P, Mogus AT, Barnes RM, Rohrer D, Lonberg N, Peabody D, Chackerian B, and Lingwood D. Engineering an antibody V gene-selective vaccine. Front Immunol. 2021, 12:738471. PMID: 34566992 View Publication
  15. Das Adhikari U, Eng G, Farcasanu M, Avena LE, Choudhary MC, Triant VA, Flagg M, Schiff AE, Gomez I, Froehle LM, Diefenbach TJ, Ronsard L, Lingwood D, Lee GC, Rabi SA, Erstad D, Velmahos G, Li JZ, Hodin R, Stone JR, Honko AN, Griffiths A, Yilmaz O, Kwon DS. Fecal SARS-CoV-2 RNA is associated with decreased COVID-19 survival. Clin Infect Dis. 2021, ciab623. PMID: 34245255 View Publication
  17. Yousif AS, Ronsard R, Shah P, Omatsu T, Sangesland M, Bracamonte Moreno T, Lam EC, Vrbanac VD, Balazs AB, Reinecker H-C, and Lingwood D. The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells. Immunity. 2021, 54:235-246. PMID: 33357409 View Publication
  19. Sangesland M, Lingwood D. Antibody Focusing to Conserved Sites of Vulnerability: The Immunological Pathways for ‘Universal’ Influenza Vaccines. Vaccines. 2021, 9:125. PMID: 33562627 View Publication
  21. Garcia-Beltran WF, Lam EC, Astudillo MG, Yang D, Miller TE, Feldman J, Hauser BM, Caradonna TM, Clayton KL, Nitido AD, Murali MR, Alter G, Charles RC, Dighe A, Branda JA, Lennerz JK, Lingwood D, Schmidt AG, Iafrate AJ, Balazs AB. COVID-19-neutralizing antibodies predict disease severity and survival. Cell. 2020, 148:476-488. PIMD:33412089 View Publication
  23. Sangesland M, Yousif A, Ronsard L, Kazer SW, Zhu AL, Gatter GJ, Hayward MR, Barnes R, Quirindongo-Crespo M, Rohrer D, Lonberg N, Kwon D, Shalek AK and Lingwood D. A single human VH gene allows for a broad-spectrum antibody response targeting bacterial lipopolysaccharides in the blood. Cell Rep. 2020, 32:108065. PMID: 32846123 View Publication
  25. Amitai A, Sangesland M, Barnes R, Rohrer D, Lonberg N, Lingwood D*, and Chakraborty A*. Defining and manipulating B cell immunodominance hierarchies to elicit broadly neutralizing antibody responses against influenza virus. Cell Syst. 2020, 11:1-16. PMID: 33031741 *co-corresponding View Publication
  27. Kaneko N, Kuo HH, Boucau J, Farmer JR, Allard-Chamard H, Mahajan VS, Piechocka-Trocha A, Lefteri K, Osborn M, Bals J, Bartsch YC, Bonheur N, Caradonna TM, Chevalier J, Chowdhury F, Diefenbach TJ, Einkauf K, Fallon J, Feldman J, Finn KK, Garcia-Broncano P, Hartana CA, Hauser BM, Jiang C, Kaplonek P, Karpell M, Koscher EC, Lian X, Liu H, Liu J, Ly NL, Michell AR, Rassadkina Y, Seiger K, Sessa L, Shin S, Singh N, Sun W, Sun X, Ticheli HJ, Waring MT, Zhu AL, Alter G, Li JZ, Lingwood D, Schmidt AG, Lichterfeld M, Walker BD, Yu XG, Padera RF Jr, Pillai S; Massachusetts Consortium on Pathogen Readiness Specimen Working Group. Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19. Cell. 2020, 183:143-157. PMID: 32877699 View Publication
  29. Ziegler, C.G.K., Allon, S.J., Nyquist, S.K., Mbano, I.M., Miao, V.N., Tzouanas,C.N., Cao, Y., Yousif, A.S., Bals, J., Hauser, B.M., Feldman, J., Muus, C., Wadsworth II., M.H., Kazer,S.W., Hughes, T.K., Doran, B., Gatter, G.J., Vukovic, M., Taliaferro, F., Mead, B.E., Guo, Z., Wang, J.P.,Gras, D., Plaisant, M., Ansari, M., Angelidis, I., Adler, H., Sucre, J.M.S., Taylor, C.J., Lin, B., Waghray,A., Mitsialis, V., Dwyer, D.F., Buchheit, K.M., Boyce, J.A., Barrett, N.A., Laidlaw, T.M., Carroll, S.L.,Colonna, L., Tkachev, V., Peterson, C.W., Yu, A., Zheng, H.B., Gideon, H.P., Winchell, C.G., Lin, P.L.,Bingle, C.D., Snapper, S.B., Kropski, J.A., Theis, F.J., Schiller, H.B., Zaragosi, L.-E., Barbry, P., Leslie, A., Kiem, H.-P., Flynn, J.L., Fortune, S.M., Berger, B., Finberg, R.W., Kean, L.S., Garber, M., Schmidt,A.G., Lingwood, D., Shalek, A.K., Ordovas-Montanes, J., HCA Lung Biological Network, SARS-CoV-2receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected inspecific cell subsets across tissues. Cell. 2020, 28:1016-1035. PMID: 32413319 View Publication
  31. Li B, Clohisey SM, Chia BS, Wang B, Cui A, Eisenhaure T, Schweitzer LD, Hoover P, Parkinson NJ, Nachshon A, Smith N, Regan T, Farr D, Gutmann MU, Bukhari SI, Law A, Sangesland M, Gat-Viks I, Digard P, Vasudevan S, Lingwood D, Dockrell DH, Doench JG, Baillie JK, Hacohen N. Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection. Nat Commun. 2020, 11:164. PMID:28827449 View Publication
  33. Keating CL, Kuhn E, Bals J, Cocco AR, Yousif AS, Matysiak C, Sangesland M, Ronsard L, Smoot M, Bracamonte Moreno T, Okonkwo V, Setliff I, Georgiev I, Balazs AB, Carr SA, Lingwood D. Spontaneous glycan reattachment following N-glycanase treatment of influenza and HIV vaccine antigens. J Proteome Res. 2020, 19:733-743. PMID:319136 View Publication
  35. Ian Setliff, Andrea R. Shiakolas, Kelsey A. Pilewski, Amyn A. Murji, Rutendo E. Mapengo, Katarzyna Janowska, Simone Richardson, Charissa Oosthuysen, Nagarajan Raju, Larance Ronsard, Masaru Kanekiyo, Juliana S. Qin, Kevin J. Kramer, Allison R. Greenplate, Wyatt J. McDonnell, Barney S. Graham, Mark Connors, Daniel Lingwood, Priyamvada Acharya, Lynn Morris, and Ivelin S. Georgiev. High-Throughput Mappingof B Cell Receptor Sequences to Antigen Specificity. Cell. 2019, 179:1636-1646. PMID:28827449 View Publication
  37. Sangesland M, Ronsard L, Kazer SW, Bals J, Boyoglu-Barnum S, Yousif AS, Barnes R, Feldman J, Quirindongo-Crespo M, McTamney PM, Rohrer D, Lonberg N, Chackerian B, Graham BS, Kanekiyo M, Shalek AK, Lingwood D. Germline-Encoded Affinity for cognate antigen enables vaccine amplification of a human broadly neutralizing response against influenza virus. Immunity. 2019, 51:735-749. PMID:28827449 Recommended in F1000Prime as being of special significance in its field

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  39. Tokatlian T, Read BJ, Jones CA, Kulp DW, Menis S, Chang JYH, Steichen JM, Kumari S, Allen JD, Dane EL, Liguori A, Sangesland M, Lingwood D, Crispin M, Schief WR, Irvine DJ. Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers. Science. 2018, 363:649-654. PMID: 30573546 View Publication
  41. Nandin IS, Fong C, Deantonio C, Torreno-Pina JA, Pecetta S, Maldonado P, Gasparrini F, Ordovas-Montanes J, Kazer SW, Kjaer S, Borley DW, Nair U, Coleman JA, Lingwood D, Shalek AK, Meffre E, Poignard P, Burton DR, Batista FD. Correction: Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies. J Exp Med. 2017, 214:2811. PMID: 28827449 View Publication
  43. Sanjuan Nandin I, Fong C, Deantonio C, Torreno-Pina JA, Pecetta S, Maldonado P, Gasparrini F, Ordovas-Montanes J, Kazer SW, Kjaer S, Borley DW, Nair U, Coleman JA, Lingwood D, Shalek AK, Meffre E, Poignard P, Burton DR, Batista FD. Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies. J Exp Med. 2017, 214:2471-2490. PMID: 28739603 View Publication
  45. Villar RF, Patel J, Weaver GC, Kanekiyo M, Wheatley AK, Yassine HM, Costello CE, Chandler KB, McTamney PM, Nabel GJ, McDermott AB, Mascola JR, Carr SA, Lingwood D. Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation. Sci Rep. 2016, 6:36298. PMID: 27796362 View Publication
  47. Weaver GC, Villar RF, Kanekiyo M, Nabel GJ, Mascola JR, Lingwood D. In vitro reconstitution of B cell receptor-antigen interactions to evaluate potential vaccine candidates. Nat Protoc. 2016, 11:193-213. PMID: 26741406 View Publication
  49. Yassine HM, Boyington JC, McTamney PM, Wei CJ, Kanekiyo M, Kong WP, Gallagher JR, Wang L, Zhang Y, Joyce MG, Lingwood D, Moin SM, Andersen H, Okuno Y, Rao SS, Harris AK, Kwong PD, Mascola JR, Nabel GJ, Graham BS. Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection. Nat Med. 2015, 21:1065-1070. PMID: 2630169 View Publication
  51. Wheatley AK, Whittle JR, Lingwood D, Kanekiyo M, Yassine HM, Ma SS, Narpala SR, Prabhakaran MS, Matus-Nicodemos RA, Bailer RT, Nabel GJ, Graham BS, Ledgerwood JE, Koup RA, McDermott AB. H5N1 Vaccine-Elicited Memory B Cells Are Genetically Constrained by the IGHV Locus in the Recognition of a Neutralizing Epitope in the Hemagglutinin Stem. J Immunol. 2015, 195:602-610. PMID: 26078272 View Publication
  53. Zhou T, Lynch RM, Chen L, Acharya P, Wu X, Doria-Rose NA, Joyce MG, Lingwood D, Soto C, Bailer RT, Ernandes MJ, Kong R, Longo NS, Louder MK, McKee K, O’Dell S, Schmidt SD, Tran L, Yang Z, Druz A, Luongo TS, Moquin S, Srivatsan S, Yang Y, Zhang B, Zheng A, Pancera M, Kirys T, Georgiev IS, Gindin T, Peng HP, Yang AS, Mullikin JC, Gray MD, Stamatatos L, Burton DR, Koff WC, Cohen MS, Haynes BF, Casazza JP, Connors M, Corti D, Lanzavecchia A, Sattentau QJ, Weiss RA, West AP, Bjorkman PJ, Scheid JF, Nussenzweig MC, Shapiro L, Mascola JR, Kwong PD. Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell. 2015, 161:1280-1292. PMID: 26004070 View Publication
  55. Lingwood D. Lipocalin 2 as a membrane-reorganizing agent. Sci Signal. 2014, 7:19. PMID: 25118326 View Publication
  57. Whittle JR, Wheatley AK, Wu L, Lingwood D, Kanekiyo M, Ma SS, Narpala SR, Yassine HM, Frank GM, Yewdell JW, Ledgerwood JE, Wei CJ, McDermott AB, Graham BS, Koup RA, Nabel GJ. Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages. J Virol. 2014, 88:4047-4057. PMID: 24501410 View Publication
  59. Lingwood D, McTamney PM, Yassine HM, Whittle JR, Guo X, Boyington JC, Wei CJ, Nabel GJ. Structural and genetic basis for development of broadly neutralizing influenza antibodies. Nature. 2012, 489:566-570. PMID: 22932267 View Publication
  61. Kaiser HJ, Surma MA, Mayer F, Levental I, Grzybek M, Klemm RW, Da Cruz S, Meisinger C, Müller V, Simons K, Lingwood D. Molecular convergence of bacterial and eukaryotic surface order. J Biol Chem. 2011, 286:40631-40637. PMID: 21965671 View Publication
  63. Kaiser HJ, Orlowski A, Róg T, Nyholm TK, Chai W, Feizi T, Lingwood D, Vattulainen I, Simons K. Lateral sorting in model membranes by cholesterol-mediated hydrophobic matching. Proc Natl Acad Sci U S A. 2011, 108:16628-16633. PMID: 21930944 View Publication
  65. Lingwood D, Binnington B, Róg T, Vattulainen I, Grzybek M, Coskun U, Lingwood CA, Simons K. Cholesterol modulates glycolipid conformation and receptor activity. Nat Chem Biol. 2011, 7:260-262. PMID: 21460830 View Publication
  67. Levental I, Lingwood D, Grzybek M, Coskun U, Simons K. Palmitoylation regulates raft affinity for the majority of integral raft proteins. Proc Natl Acad Sci U S A. 2010, 107:22050-22054. PMID: 21131568 View Publication
  69. Lingwood D, Simons K. Lipid rafts as a membrane-organizing principle. Science. 2010, 327:46-50. PMID: 20044567 View Publication
  71. Lingwood D, Schuck S, Ferguson C, Gerl M, Simons K. Morphological homeostasis by autophagy. Autophagy. 2009, 5:1039-40. PMID: 19587538 View Publication
  73. Lingwood D, Kaiser HJ, Levental I, Simons K. Lipid rafts as functional heterogeneity in cell membranes. Biochem Soc Trans. 2009, 37:955-960. PMID: 19754431 View Publication
  75. Kaiser HJ, Lingwood D, Levental I, Sampaio JL, Kalvodova L, Rajendran L, Simons K. Order of lipid phases in model and plasma membranes. Proc Natl Acad Sci U S A. 2009, 106:16645-16650. PMID: 19805351 View Publication
  77. Lingwood D, Schuck S, Ferguson C, Gerl MJ, Simons K. Generation of cubic membranes by controlled homotypic interaction of membrane proteins in the endoplasmic reticulum. J Biol Chem. 2009, 284:12041-12048. PMID: 19258319 View Publication
  79. Lingwood D, Ries J, Schwille P, Simons K. Plasma membranes are poised for activation of raft phase coalescence at physiological temperature. Proc Natl Acad Sci U S A. 2008, 105:10005-10010. PMID: 18621689 View Publication
  81. Lingwood D, Simons K. Detergent resistance as a tool in membrane research. Nat Protoc. 2007, 2:2159-2165. PMID: 17853872 View Publication
  83. Lingwood D, Harauz G, Ballantyne JS. Decoupling the Na+-K+-ATPase in vivo: a possible new role in the gills of freshwater fishes. Comp Biochem Physiol A Mol Integr Physiol. 2006, 144:451-457. PMID: 16730202 View Publication
  85. Lingwood D, Ballantyne JS. Alkaline phosphatase-immunoglobulin conjugate binds to lipids in vitro, independent of antibody selectivity. J Immunol Methods. 2006, 311:174-177. PMID: 16524587 View Publication
  87. Lingwood D, Harauz G, Ballantyne JS. Regulation of fish gill Na(+)-K(+)-ATPase by selective sulfatide-enriched raft partitioning during seawater adaptation. J Biol Chem. 2005, 280:36545-36550. PMID: 16096276 View Publication
  89. Lingwood D, Fisher LJ, Callahan JW, Ballantyne JS. Sulfatide and Na+-K+-ATPase: a salinity-sensitive relationship in the gill basolateral membrane of rainbow trout. J Membr Biol. 2004, 201:77-84. PMID: 15630545 View Publication
  91. Binnington B, Lingwood D, Nutikka A, Lingwood CA. Effect of globotriaosyl ceramide fatty acid alpha-hydroxylation on the binding by verotoxin 1 and verotoxin 2. Neurochem Res. 2002, 27:807-813. PMID: 12374217 View Publication